Yes—pellet therapy has been used for many decades and is considered a safe delivery method when done properly. Common side effects are typically mild and include slight bleeding, bruising, or redness at the insertion site. Pellet extrusion (the pellet pushing out) is rare (less than 1%) with high-quality pellet methods like EvexiPEL®.

The pellets are made of bioidentical, plant-derived hormones (such as estradiol or testosterone) that are molecularly matched to the hormones your body naturally produces. They also include inert binders to hold the pellet together. 

The procedure is typically done in about 10–15 minutes in-office. A small area (usually hip or buttock) is numbed with local anesthesia, a tiny incision is made, and the pellet is placed under the skin in the fatty tissue. You’ll be dressed and given aftercare instructions.

It depends on your metabolism, activity level, and how your body absorbs the hormone. For most women, pellets last about 3 to 5 months; for men, 5 to 7 months is common. 

Pellets deliver a steady hormone release—no daily dosing, fewer fluctuations, and greater convenience. They mimic your body’s natural hormonal rhythms better than pills or creams, which often cause peaks and valleys. 

While generally mild, side effects may include:

• Minor bleeding, bruising, or discoloration at the insertion site
• Pellet extrusion (rare)
• Skin irritation or soreness
• Hormonal adjustment symptoms (acne, hair changes, mood shifts)
  Most of these resolve with time or minor management.

The individual hormones used (e.g. estradiol, testosterone) are FDA-approved. However, the pellet insertion method (the surgical procedure) as a delivery device is not specifically FDA-approved because it involves compounding and individualized use. 

Yes. Women naturally produce testosterone (in ovaries and adrenal glands). As levels drop with age or other factors, symptoms like low libido, mental fog, muscle weakness, and weight gain may appear. Testosterone pellets can restore balance safely under medical supervision.

Pellet therapy isn’t suitable for all. Patients with certain cancers, uncontrolled cardiovascular disease, or contraindications may be excluded. Your provider will review your medical history, labs, and risk before recommending it.

For women, pellets typically release hormones for 3–5 months, while for men, they last about 4–6 months, depending on individual needs and absorption rates.

Some clients notice improvements in mood, energy, and libido within 7–10 days. However, the full range of benefits usually becomes noticeable within 2–4 weeks.

Yes. Pellet therapy is completely optional, and you can discontinue at any time under medical supervision. However, many clients choose to continue because of the significant improvement in quality of life.

Pellet insertion is a quick, in-office procedure performed under local anesthesia. Most clients report only minor pressure or discomfort at the insertion site, which resolves quickly.

Yes. To ensure safety and effectiveness, we require regular lab testing and follow-up visits. These allow us to adjust dosing if needed and maintain optimal balance.